Classification of coronary heart disease using the multi-layer perceptron neural networks

(1) Fatih Ikhwandoko Mail (Faculty of Industrial Technology, Informatics Department, Ahmad Dahlan University, Indonesia)
(2) * Dewi Pramudi Ismi Mail (Faculty of Industrial Technology, Informatics Department, Ahmad Dahlan University, Indonesia)
*corresponding author

Abstract


Coronary heart disease (CHD) is one of the leading causes of death worldwide. The complexity of risk factors such as blood pressure, cholesterol, smoking history, and unhealthy lifestyles often makes the diagnosis process less effective. With the increasing need for fast and accurate heart disease prediction systems, the use of artificial intelligence-based methods such as Neural Networks is a promising solution. This study aims to evaluate the ability of the Multi-Layer Perceptron (MLP) algorithm to classify CHD risk using the Framingham Heart Study dataset, while comparing it with other commonly used classification methods. This research used the collection of Framingham heart disease data containing 15 medical features. The data was then processed through cleaning, normalization, and class balancing using the SMOTE method. An MLP model was designed with two hidden layers using 200 and 128 neuron architectures, and tested in three training and testing data split scenarios (70:30, 75:25, and 80:20). The model was trained for 100 epochs and evaluated using accuracy, precision, and recall metrics to assess its classification performance. The experiment results show that MLP is able to produce high performance with 86.20% accuracy. 84.40% precision, and 88.56% recall. Compared to other methods such as Decision Tree and SVM, the experiment results show that MLP demonstrated superior classification accuracy. Thus, MLP has the potential to be an effective tool for supporting early diagnosis of coronary heart disease more intelligently and efficiently


Keywords


coronary heart disease; neural networks; multi layer perceptron; classification; framingham heart study

   

DOI

https://doi.org/10.31763/sitech.v6i1.2186
      

Article metrics

10.31763/sitech.v6i1.2186 Abstract views : 26 | PDF views : 7

   

Cite

   

Full Text

Download

References


[1] J. L. Rodgers et al., “Cardiovascular Risks Associated with Gender and Aging,” J. Cardiovasc. Dev. Dis., vol. 6, no. 2, p. 19, Apr. 2019, doi: 10.3390/jcdd6020019.

[2] S. Saheera and P. Krishnamurthy, “Cardiovascular Changes Associated with Hypertensive Heart Disease and Aging,” Cell Transplant., vol. 29, p. 096368972092083, Jan. 2020, doi: 10.1177/0963689720920830.

[3] V. Regitz-Zagrosek and C. Gebhard, “Gender medicine: effects of sex and gender on cardiovascular disease manifestation and outcomes,” Nat. Rev. Cardiol., vol. 20, no. 4, pp. 236–247, Apr. 2023, doi: 10.1038/s41569-022-00797-4.

[4] “Cardiovascular diseases (CVDs),” Wordl Health Organization, 2025. [Online]. Available at: https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds).

[5] M. Rafieian-Kopaei, M. Setorki, M. Doudi, A. Baradaran, and H. Nasri, “Atherosclerosis: Process, Indicators, Risk Factors and New Hopes,” Int. J. Prev. Med., vol. 5, no. 8, p. 927, 2014,. [Online]. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC4258672/.

[6] B. Dhakal, MD and B. Pokharel, MD, “Coronary Artery Disease (CAD) Demystified - Causes, Symptoms & Treatment,” Am. J. Patient Heal. Info, vol. 1, no. 01, pp. 1–9, Jul. 2024, doi: 10.69512/ajphi.v1i01.37.

[7] R. Prajapati, P. Patel, and U. Upadhyay, “A Review On Coronary Artery Disease,” World J. Pharm. Res. Formul., vol. 2, no. 5, pp. 1685–1703, 2021, [Online]. Available at: https://wjpr.s3.ap-south-1.amazonaws.com/article_issue/4086ee5b0f776501b4dc42c0d4cb1939.pdf.

[8] N. Sulashvili and R. R. Nimangre, “Manifestation Of Some Aspects Of Cardiovascular Diseases, Implications, Pharmacotherapeutic Strategies, Effects, Impacts And Potential Hazards In General,” Jr. Res., vol. 3, no. 1, pp. 1–27, Feb. 2025, doi: 10.52340/jr.2025.03.01.01.

[9] J. L. Ferreir, S. Kumar, A. Soni, N. Acharya, and S. Acharya, “Clinical Management of Cardiovascular Diseases,” in Current Trends in the Diagnosis and Management of Metabolic Disorders, Boca Raton: CRC Press, 2023, pp. 254–278, doi: 10.1201/9781003384823-15.

[10] N. Khan, A. Akbar, S. Fahad, S. Faisal, and M. Naushad, “Analysis of Heart Treatment and Its Impact on Socioeconomic Conditions on the World Community,” SSRN Electron. J., p. 59, Nov. 2020, doi: 10.2139/ssrn.3727588.

[11] R. Parizad, A. Batta, J. Hatwal, M. Taban-sadeghi, and B. Mohan, “Emerging risk factors for heart failure in younger populations: A growing public health concern,” World J. Cardiol., vol. 17, no. 4, p. 104717, Apr. 2025, doi: 10.4330/wjc.v17.i4.104717.

[12] A. Foley, G. Regan, and C. Rush Thompson, “Prevention Practice for Cardiopulmonary Conditions,” in Prevention Practice and Health Promotion, New York: Routledge, 2024, pp. 225–239, doi: 10.4324/9781003525882-14.

[13] J. Knuuti et al., “2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes,” Eur. Heart J., vol. 41, no. 3, pp. 407–477, Jan. 2020, doi: 10.1093/eurheartj/ehz425.

[14] Y. Mao, B. L. Jimma, and T. B. Mihretie, “Machine learning algorithms for heart disease diagnosis: A systematic review,” Curr. Probl. Cardiol., vol. 50, no. 8, p. 103082, Aug. 2025, doi: 10.1016/j.cpcardiol.2025.103082.

[15] Y. Kumar, A. Koul, R. Singla, and M. F. Ijaz, “Artificial intelligence in disease diagnosis: a systematic literature review, synthesizing framework and future research agenda,” J. Ambient Intell. Humaniz. Comput., vol. 14, no. 7, pp. 8459–8486, Jul. 2023, doi: 10.1007/s12652-021-03612-z.

[16] F. Yasmin et al., “Artificial intelligence in the diagnosis and detection of heart failure: the past, present, and future,” Rev. Cardiovasc. Med., vol. 22, no. 4, pp. 1095–1113, Dec. 2021, doi: 10.31083/j.rcm2204121.

[17] P. Mathur, S. Srivastava, X. Xu, and J. L. Mehta, “Artificial Intelligence, Machine Learning, and Cardiovascular Disease,” Clin. Med. Insights Cardiol., vol. 14, p. 117954682092740, Jan. 2020, doi: 10.1177/1179546820927404.

[18] V. Chang, V. R. Bhavani, A. Q. Xu, and M. Hossain, “An artificial intelligence model for heart disease detection using machine learning algorithms,” Healthc. Anal., vol. 2, p. 100016, Nov. 2022, doi: 10.1016/j.health.2022.100016.

[19] N. Ghaffar Nia, E. Kaplanoglu, and A. Nasab, “Evaluation of artificial intelligence techniques in disease diagnosis and prediction,” Discov. Artif. Intell., vol. 3, no. 1, p. 5, Jan. 2023, doi: 10.1007/s44163-023-00049-5.

[20] “Framingham Heart Study Longitudinal Data Documentation for Teaching Dataset,” National Institute of Health (NIH), 2024. [Online]. Available at: https://share.google/lmHyeueYC329Vn4wf.

[21] “Axon,” Wikipedia, 2024. [Online]. Available at: https://simple.wikipedia.org/wiki/Axon.

[22] J.-J. Beunza et al., “Comparison of machine learning algorithms for clinical event prediction (risk of coronary heart disease),” J. Biomed. Inform., vol. 97, p. 103257, Sep. 2019, doi: 10.1016/j.jbi.2019.103257.


Refbacks

  • There are currently no refbacks.


Copyright (c) 2025 Fatih Ikhwandoko, Dewi Pramudi Ismi

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

___________________________________________________________
Science in Information Technology Letters
ISSN 2722-4139
Published by Association for Scientific Computing Electrical and Engineering (ASCEE)
W : http://pubs2.ascee.org/index.php/sitech
E : sitech@ascee.org, andri@ascee.org, andri.pranolo.id@ieee.org

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0

View My Stats